Production of AAV at the 1,000 L scale
Download the application note to learn more about how to implement scalable and robust AAV production and purification strategies
Prior work has demonstrated scalability of the Gibco CTS AAV‑MAX Helper‑Free AAV Production System to produce AAV in the Thermo Scientific DynaDrive Single‑Use Bioreactor (S.U.B.) at the 50 L scale. As further continuation of that work, this study showcases scaling this same process up to a commercial manufacturing scale of 1,000 L working volume in the 5,000 L DynaDrive S.U.B., along with specific guidance on how to successfully perform these processes at this scale.